Normal Values for the Study of the Concentration of Serum Creatinine
The concentration of creatinine in the serum depends mainly on muscle mass, sex (in men higher than in women), and, in addition, on the amount of meat consumed (with a large consumption of creatinine, the concentration of blood in the blood can significantly increase). However, in a particular person, the serum creatinine concentration is relatively constant.
Because creatinine is not absorbed back, nor secreted by the kidneys, and its amount in the urine depends almost exclusively on the filtration function of the kidneys, the determination of serum creatinine and urine concentrations has found wide application in assessing kidney function. An increase in the concentration of creatinine in the blood (growth of creatininemia) occurs with acute and chronic renal failure.
The permissible concentration of serum creatinine
To indicate the concentration of creatinine, a sample of venous blood is taken, mainly from the ulnar vein. It is necessary to come for an examination on an empty stomach. Under normal conditions, the concentration of creatinine in the blood is in the range of 53 to 115 μmol / L (0.6 to 1.3 mg%). This value, however, depends on the age, weight, sex of the patient, his weight, and consumption of meat in the diet. In addition, one should remember the possibility of obtaining false results when the sample is hemolyzed or the patient has hyperbilirubinemia.
Determination of serum creatinine concentration is most often used to calculate the so-called endogenous creatinine, according to a special formula. The value obtained in this way is a good indicator of assessing the filtration function of the kidneys.
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When using creatinine concentration in the blood to assess kidney function, however, care should be taken because the concentration rises only when at least half of the pulp of the kidneys is damaged. In addition, in older people, depleted and with a small muscle mass, the creatinine concentration in the blood may be low, despite impaired renal function.
Interpretation of serum creatinine concentration
An increase in the serum creatinine concentration indicates a disorder in the filtration function of the kidneys.
This occurs in both acute and chronic renal failure. Because of this, to the reasons for the growth of creatinine, we can include all these diseases, which are the cause of acute and chronic renal failure.
Among the most common reasons are:
- Kidney ischemia – in the process of shock (cardiogenic, septic, anaphylactic, hemorrhagic), with desiccation during acute diarrhea and vomiting;
- Primary and secondary damage to the pulp of the kidneys during systemic lupus erythematosus, diabetes mellitus, amyloidosis, glomerular inflammation of the kidney, tubulointerstitial inflammation of the kidneys, with sclerosis, damage by toxins or nephrotoxic drugs;
- Difficulty urinary outflow or complete obstruction of the urinary tract, caused by urolithiasis, blood clots, squeezing of the urinary tract.
All these conditions can cause acute or chronic renal failure and impairment of the filtration function of the kidneys. In turn, the violation of renal filtration leads to a decrease in the filtration of creatinine and an increase in its concentration in the blood serum. Because of this, the determination of the concentration of creatinine in the blood is a good indicator for assessing the work of the kidneys.
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It should also be remembered that a slight increase in creatinine concentration may be due to muscle mass gain or the use of nutritional supplements containing creatine in its composition. Reducing the concentration of creatinine in the blood is rare. Its cause may be fasting, loss of muscle or the use of corticosteroids. It can also occur during pregnancy.